Recombinant hirudin anticoagulation for aortic valve replacement in heparin-induced thrombocytopenia
نویسندگان
چکیده
منابع مشابه
Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia. Heparin-Associated Thrombocytopenia Study (HAT) investigators.
BACKGROUND We prospectively investigated lepirudin for further parenteral anticoagulation in patients with heparin-induced thrombocytopenia (HIT). METHODS AND RESULTS Patients with confirmed HIT (n=112) received lepirudin according to need for 2 to 10 days (longer if necessary): A1, treatment: 0.4 mg/kg IV bolus, followed by 0.15 mg. kg(-1). h(-1) intravenous infusion, n=65; A2, treatment in ...
متن کاملLepirudin (Recombinant Hirudin) for Parenteral Anticoagulation in Patients With Heparin-Induced Thrombocytopenia
Background—We prospectively investigated lepirudin for further parenteral anticoagulation in patients with heparininduced thrombocytopenia (HIT). Methods and Results—Patients with confirmed HIT (n5112) received lepirudin according to need for 2 to 10 days (longer if necessary): A1, treatment: 0.4 mg/kg IV bolus, followed by 0.15 mg z kg z h intravenous infusion, n565; A2, treatment in conjuncti...
متن کاملRecombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: a prospective study.
BACKGROUND The immunological type of heparin-induced thrombocytopenia (HIT) is the most frequent drug-induced thrombocytopenia. This study evaluated the efficacy of recombinant hirudin (r-hirudin or lepirudin), a potent thrombin inhibitor, for anticoagulation in patients with confirmed HIT. METHODS AND RESULTS Eighty-two patients in this prospective, multicenter study received 1 of 4 intraven...
متن کاملHeparin induced thrombocytopenia
Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
متن کاملRapid anticoagulation using ancrod for heparin-induced thrombocytopenia.
In order to determine the efficacy and safety of ancrod, a rapid acting defibrinogenating drug, for patients with heparin-induced thrombocytopenia, 11 consecutive patients who required anticoagulant therapy because of venous thromboembolism and who developed acute heparin-induced thrombocytopenia or had a history of heparin-induced thrombocytopenia were treated with ancrod. Heparin therapy was ...
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ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
سال: 2000
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03018923